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To establish a direct association between HMGA1 and HK2 transcription, we introduced mutations into the HMGA1 binding sites within the HK2 promoter and subsequently conducted a luciferase reporter assay to evaluate HMGA1s specific binding capability to the HK2 promoter

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A survey of 20 million patient records revealed that MS and gout are mutually exclusive diagnoses [156]

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Previous work from our and other labs has demonstrated that mitochondrial GSH is critical for cell viability, and indeed we find that cells with uncoupled mitochondrial and cytosolic GSH remain sensitive to inhibition of mitochondrial GSH transport or disruption of mitochondrial functionality